Van de Ven Brace Halts The Toffees' Run at Brand New Home Ground
The Dutch defender emerged as the initial backline player to net twice in a Premier League game for Spurs since Jan Vertonghen in March 2013.
Match summary
The Spurs defender heads into the net two times in first half
Everton's defender has equalizer disallowed after video check
Senegalese midfielder nets final goal in 89th minute
This loss is Everton's initial at their new ground
The Tottenham defender scored twice as Tottenham prolonged their unbeaten run on the road in the top division and handed Everton their first defeat at Hill Dickinson Stadium.
The Toffees were undefeated in their five previous fixtures at their recently opened stadium at the dockside location, having departed their historic home behind after more than a century at the end of the previous campaign.
But Spurs captain Van de Ven pounced twice from corners in the opening 45 minutes to place their strong form at risk, and they were failed to turn it around before the midfielder - set up by former Toffees attacker Richarlison - headed home a third to put the game to bed.
Jake O'Brien thought he had equalized the scores five minutes after Van de Ven's opener, glancing a bullet header past the Spurs keeper from an set-piece.
Beto, in the meantime, failed to convert a handful of chances, while Vicario made a series of excellent saves to ensure the London club went five matches on the road without defeat in the English top flight.
But the video assistant referee intervened, advising the match official to check the score on the screen and the official decided that Jack Grealish and Iliman Ndiaye were in offside positions and had interfered with the Spurs keeper.
The win moves the manager's side up to third in the division, five points off north London rivals and table-toppers Arsenal.
Everton stay in 14th position and sit half a dozen points ahead of the relegation zone.
Spurs breakdown: Van de Ven fulfils role at each end of the field
After a uninspiring midweek performance in the Champions League against the French side, where they mustered a only two shots on goal, the manager chose Randal Kolo Muani up front instead of former Toffees player the Brazilian.
The summer signing was unable to make much of an impact before being substituted for the substitute after an hour on the pitch, but it turns out he wasn't needed in the final outcome.
Centre-back Van de Ven transformed into an offensive threat to be feared.
Tottenham's opening strike came from a cleverly executed set-piece play, with the midfielder directing the ball back across the six-yard box for an unmarked the defender to head home.
And the captain - filling in as captain in the Argentine's unavailability - added his second in added time as he rose above the England keeper to nod in.
Van de Ven was equally outstanding in defensive duties, partnering effectively with Kevin Danso as the duo handled excellently with the numerous deliveries sent their way by the opposition.
Everton analysis: Everton missing striker's instinct
The club's new home had been a fortress, but it appears the novelty may have faded somewhat and supporters flocked to the exits after the midfielder's final goal for Tottenham.
The end in the team's unbeaten home run won't be a massive worry for David Moyes, but their striker situation will be.
Beto and Thierno Barry - the Everton's two established centre-forwards - had netted only a single goal between them before Sunday's outing.
And they were failed to add to that miserable record on a wet and gloomy night on in Liverpool.
The striker's form was summed up when he opted to overhead kick a clear chance from near the goal, despite having room and time to reposition for a more conventional shot that would have challenged the keeper.
The substitute, as well, was unable to make an impact after replacing the starter in the second half.
It was not for a lack of opportunity. Most of Everton's offensive moves came through the winger and the forward, who relentlessly delivered dangerous crosses into the Tottenham box.
What next for both teams?
The Toffees: The team travel to Sunderland in the Premier League on early November at 20:00 GMT.
Tottenham: The London club travel to Newcastle's ground on late October for their fourth-round League Cup match against the Magpies.